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grades of inammation were from focal to diffuse according to lamina propria inltration or subendothelial inltration

In vivo rodent studies have investigated BPC-157 across gastrointestinal ulcer models, tendon and ligament transection models, and peripheral nerve injury paradigms, with research examining angiogenesis and new-vessel and granulation-tissue formation in both gastrointestinal mucosa and musculoskeletal tissue [3][4], alongside collagen deposition kinetics and, in a separate body of central nervous system work, dopaminergic and serotonergic system dynamics, following both systemic and local administration

It is reported that 5-ASA ameliorates UC in mice through dual mechanisms of preserving intestinal epithelial barrier integrity and modulating gut microbiota composition, with concomitant suprpression of JNK and p38 MAPK phosphorylation in colonic macrophages (Qu et al., 2017

Tissue Barriers (2016) 4(4):e1251384